Have a look at the last fine post from Chris Glazier.
Additional some hints for the newer Windows operating systems: Our own application (32 Bit) developed with Net Express 5.1 on Windows 7 runs on Windows Server 2012 R2 and one first test on Windows 10 seemed to be ok. Our application is deployed together with the Micro Focus Server (runtime system for Net Express).
If your application is build similar i would suggest that you check the versions of Net Express and Micro Focus Server - they always should be on the same WrapPack level. The recent WrapPack 13 is available, may be it helps. At last have a look at 32-/64-bit issues.
Regards and good luck