I have to also mention that the OP (Original Poster) is using wrap pack 12 and running Windows 10.
When running the application the CBL_DEBUGBREAK is either totally ignored or sometimes prompts. When it prompts NetExpress loads and then crashes.
If you load NetExpress and set wait for animation then this works every time (This is what the OP is using as a work around).
We have also tried deleting the HKEY_CURRENT_USER\SOFTWARE\Micro Focus\NetExpress registry key. (These get recreated and you'd have to redo your preferences) We have found something gets corrupt and NetExpress would fail with a 114 error.
Additionally we also deleted the NetExpress workspace file as this sometimes becomes corrupt.
Uninstalling, reinstalling or repairing NetExpress results in the same problem
In the past when this has occurred on other developers machines it becomes a total machine reload a very costly exercise in terms of time.
Neil